Bioreactors
Bioprocess Development
Asia Mattelab is the authorized distributor for H.E.L Group Bioreactors in Singapore.
Elevate your bioprocessing capabilities with H.E.L Group’s adaptable and innovative BioXplorer range. The modular design increases flexibility and enables tailored solutions for diverse bioprocesses. Choose from an array of customizable configurations with seamless integration of third-party equipment.
From applications ranging from aerobic fermentation to high-pressure syngas fermentation, the BioXplorer product range delivers optimized solutions. Parallel reactor setups allow for efficient screening, harnessing robust control features to manipulate reactors, capture analytics, and fine-tune parameters.
Reduce costs, streamline operations, and reduce error risks while obtaining ‘real bioreactor’ insights. With H.E.L Group’s expertise, collaborative spirit, robust support, and exceptional service, our BioXplorer range can reshape your bioprocessing journey.
BioXplorer 100 | bench-top, parallel 8 bioreactor platform
The BioXplorer 100 is a multi-bioreactor system designed for the optimization of aerobic fermentations. With a working volume as low as 50 ml, the BioXplorer 100 allows for low-working volume processes. The design of the bioreactor’s lid enables customizable configurations, choosing from a wide range of probes and feeds. Controlled by WinISO, BioXplorer is designed to be a fully automatized system.
Overview
Customizable configurations
The BioXplorer 100 features 8 configurable bioreactors, allowing working volumes ranging from 50-150ml. The reactors can be controlled independently or in parallel with a range of probe/sensor configurations available. The system’s modular design allows precise additions of liquids and gases, controlled by up to four sets of eight peristaltic pumps and up to two sets of mass flow controllers.
Optimized solutions for a range of applications
The BioXplorer 100 is optimized for aerobic fermentation and optimal growth. The highly configurable system allows more in-depth process insights and comprehensive data, enabling you to understand your processes better. A huge advantage of the BioXplorer 100 is the increased productivity from the eight parallel reactors, as they simultaneously allow the screening and high throughput of multiple processes. Paired with WinISO, data acquisition in real-time can be used for monitoring the fermentation, and processes can be controlled live through the design of feedback loops.
Flexibility and control
BioXplorer 100 is equipped with a highly customizable range of sensors optimized for the process, allowing for the acquisition of high-throughput data in real-time. BioXplorer 100 is controlled by H.E.L’s WinISO, allowing for strict control of the parameters of the bioprocess. The automatization of processes based on on-line measurements allows for response to changes in the bioreactor through feedback loops.
Compact Parallel Bioreactors
Space and cost-efficient, the BioXplorer 100’s small bioreactors allow up to eight parallel bioprocesses to be run in a system with a small overall footprint. In contrast, the system’s low working volume (50 – 150 ml) minimizes reagent costs and fermentation times. Although small in size, the bioreactors have been designed to be easy to use and for flexibility in sensor configuration to allow real-time data collection in real bioreactor settings. The BioXplorer 100 offers an intelligent solution to overcome bioprocessing challenges.
BioXplorer 400 | bench-top, parallel 4 bioreactor platform
The BioXplorer 400 is equipped with 4 bioreactors with working volumes of up to 400 ml. It is a fantastic tool for parallel bioprocess optimization. The highly configurable nature of their lid expands the testing capability for the bioprocess, choosing which probes to use to characterize in real time the critical parameters for the fermentation. Combined with H.E.L’s WinISO allows for the full automatization of aerobic fermentation.
Overview
Parallel Bioreactor
The BioXplorer 400 has four bioreactors, allowing working volumes from 120 ml to 400ml, each meticulously optimized for aerobic fermentation. These bioreactors form the foundation of your bioprocessing endeavors, allowing you to undertake up to four parallel bioprocesses simultaneously. Whether it’s in-depth experimentation, parallel screening, or accelerated research, the BioXplorer 400 offers many possibilities.
Flexibility & Control
The wide range of probes available with the BioXplorer 400 enables the monitoring of critical parameters for the bioprocess for in-depth characterization. The responsiveness of WinISO allows for the fine control of critical parameters in fermentation through the implementation of automated feedback loops.
BioXplorer 400 is an incredible tool for the characterization and optimization of processes. The customizable configuration of the bioreactors allows for the careful selection of the parameters to track during the fermentation. With a choice of agitation, either magnetic or overhead, which enables a wider range of impellor speeds, allowing cultivation of shear sensitive cells at lower speeds. Higher impellor speeds increase gas transfer for increased cell densities or product yields.
BioXplorer 400P | High-pressure bench-top, parallel 4 bioreactor platform
The BioXplorer 400P is an automated parallel pressure bioreactor system for the discovery and optimization of novel bioprocesses. Designed for applications ranging from syngas fermentation to cell-free enzymatically catalyzed processes, the BioXplorer 400P uses pressure and precision gas control to accelerate bioprocesses, which depend on the availability of dissolved gases.
The customizable configuration combined with versatile software allows the BioXplorer 400P to fulfill your precise needs, giving you the data you need to scale up faster.
Overview
Pressurized Bioprocessing
The BioXplorer 400P’s ability to run up to four parallel bioprocesses at up to 10 bar pressure is unique. More and more bioprocess scientists are turning to pressurized systems to increase the availability of dissolved gases and accelerate gas-dependent bioprocesses. The BioXplorer 400P is an indispensable tool for the optimization and scale-up of such processes. The system has been engineered with a focus on safety and ease of use. For example, the use of 2 gas spargers per reactor enables risks associated with potentially hazardous gas mixtures to be minimized. Adding pressure to accelerate your bioprocesses can deliver higher yields without compromising functionality and configurability.
Configurable System
The BioXplorer 400P uses a modular design and can be supplied with a wide range of probes, gas feeds, and liquid feeds, enabling it to be tailored to your precise needs. This maximizes functionality and ease of use while minimizing bench space requirements and cost.
Flexibility to optimize processes
The choice of probes to track the wide range of physicochemical parameters in bioprocess provides in-depth knowledge. Using H.E.L’s WinISO tight control and responsiveness, automatization of the process is possible. BioXplorer 400P can operate 4 bioreactors in parallel or independently, reducing the optimization time of bioprocesses.
BioXplorer 400XL | Expanded Bench-Top, Parallel 8 Bioreactor Platform
Featuring eight 500 ml bioreactors, the BioXplorer 400XL allows the fast optimization of critical parameters for aerobic fermentations. The parallel bioprocess capabilities of BioXplorer 400XL, combined with the customizable configuration of the bioreactor lid, unlocks the possibility of choosing what parameters to measure in real-time. Combined with the WinISO, the BioXplorer 400XL is able to respond to the change happening in the bioprocess, allowing for complete automatization of the fermentation.
Overview
Enhanced Bioreactor System
The BioXplorer 400XL has eight bioreactors, each optimized for aerobic fermentation and each allowing 120 mL – 400 mL working volume. These bioreactors can be equipped with a wide variety of probes and sensors, and the system offers multiple gas and liquid feed configurations. The ability to precisely control and monitor up to eight bioprocesses in parallel greatly accelerates screening and optimization studies, leading to more profound process knowledge and faster scale-up.
Flexibility and control
BioXplorer 400XL combines increased larger volumes with the replication and parallelization capabilities of having eight independent reactors controlled by WinISO. This software monitors the parameters of interest in the bioreactor and, at the same time, permits stringent control over them, always maintaining ideal conditions within the reactor. Combined with the ability to customize and the flexibility and variety of liquid and gas pumps and agitation, it results in great tools to characterize and optimize bioprocesses.
BioXplorer 5000 | Lab-scale bioreactor platform
The BioXplorer 5000 and 5000P single bioreactor systems are ideally suited to drive your scale-up efficiency. These systems are highly automated and highly customizable. The BioXplorer 5000P is the ideal choice for pressure applications up to 10 bar, ranging from syngas fermentation to processes driven by cell-free biocatalysis.
Features
The BioXplorer 5000 and 5000P single bioreactor systems are suitable for a wide range of applications including syngas fermentation and cell-free biocatalysis with:
- Automated inventory monitoring
- BioVIS optical probe to monitor cell density trends without taking samples
- Choice of reactor sizes and types, including elevated pressure designs (up to 10 bar)
- Fully automated control
Software
The H.E.L control software runs the BioXplorer 5000 system, enabling complex, fully automated experiments to run unattended.
This enables:
- Full reactor control with unlimited step recipe planning. Plans can be changed online at any time without process interruption
- The individual reactor temperature and agitation control
- User-defined data-logging with customizable tabular and graphical displays
- Export data functions and integration with in-house electronic lab notebooks and record-keeping systems
- DoE and QbD package integration
BioVIS | An Inline Cell Density Indicator Sensor
BioVIS is a probe for the inline monitoring of total cell growth and biomass within a bioreactor, enabling culture growth kinetics to be tracked and logged. It removes or reduces the need for online sampling, thereby simplifying measurements, reducing contamination risks, and conserving the culture media volume.
The probe can be produced at any length, making it suitable for any desired vessel size, and it is compatible with all major brands of bioreactors. The BioVIS Multiplex is designed for use with multiple bioreactors, enabling total cell density to be tracked across all parallel cultures
Tandem Off Gas Analyzers | Multi Line and Continuous Systems
The Tandem gas analyzer systems will give you real-time, on-line data that helps you understand and control your cell culture experiments. Specifically designed for CO2 and O2 exhaust gas analysis from cell culture experiments, the tandem range fits onto a wide range of systems, from different manufacturers. These off-gas analyzers come in both continuous and multi-line configurations.
Features
- Get deeper understanding of your cell cultures on-line
- With greater control, increase the reliability and repeatability of your process
- Automate your processes and controls, based on real-time feedback
- Flexible design allows the same data to be recovered from all your reactors